A popular folk remedy for heartburn as a proton pump inhibitor, the possibility of death, new research shows.
It is not the first time that the drug, also known as PPI is associated with health risks. Previous studies have linked drugs for kidney problems, dementia and bone fractures, although not all studies agreed.
In a new study, the likelihood of dying increases the time people are using drugs, according to senior student author Ziyad Al-Aly, MD, the clinical epidemiology at the VA San Luis healthcare system’s Director.
For more than five years, their team of people who took the PPI recipe like Nexium and persecuted them. Compared with those taking other drugs, gastric acid from H2 blockers (Zantac or the like) is known pepsin. The studies have not been taken into use PPI medications are available without prescription.
Compared with the blocking of H2 users, “people getting PPI for about a year, about 25% higher risk of death,” says Al-Aly, who is also a professor of medicine at the University of Washington faculty professor St. Louis medicine.
Since millions of people regularly take the PPI, this is a 25% in the thousands of dead could translate annually, Al-Aly said.
However, the study is only association, does not prove cause and effect
A representative of the industry shows that drugs are safe when people follow the instructions on the label.
The people who use drugs that should not stop, says Al-Aly. “I would say this is a small but significant risk,” he says. “This is to encourage us to look at whether the PPI is primarily or not.”
TAD and is one of the most widely used drugs in the United States, with 15 million monthly recipes for Nexium in 2015, according to market research companies IMS types.
Although the recommended therapy treatment for the most little too short – 2-8 weeks for ulcers, for example – many people taking drugs at the end for months or years. In some patients, the doctors found that the use of more justified, and the study found that the chances of death greatly increased when the PPI imposed regulations for more than a year.
Receptirane versions of both PPI and H2 blockers treat severe disorders such as upper gastrointestinal bleeding, gastroesophageal reflux disease (GERD), and ulcers. Versions with small dose counters are typically used to treat heartburn and digestive disorders.
The study did not receive any funding from the industry. It was released online in BMJ Open.